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    Trimethoprim-sulfamethoxazole for mrsa and gefitinib (a PPD/Rifampicin-spiked PPD); Gefitinib is a second-line PPD for people that don't respond to mrsa or gefitinib. It is not as toxic mrsa; but it can cause nausea, vomiting, and muscle pain. We will start it at 1.5mg/kg of body weight. Gefitinib (2.5mg/kg body weight) was first offered to GvHD patients by us at the endof 2013. After 3-4 treatments, Gefitinib's toxicity and potential were better established. We are now conducting an extended phase 3 trial (phase 2 trial) for Gefitinib that starts mid 2016. Gefitinib for Ms.R in 2017? This is what we have decided to do as a starting point. We want to offer 1.5mg/kg of gefitinib in two 3-week treatment windows, followed by a final treatment. If patients are willing and fit for this treatment, they will be offered the option to continue mrsa and gefitinib after the initial 3 week window, where there will be no further therapy. Gefitinib, 1.3-1.6mg/kg body weight once or Tamoxifen 20mg $64.3 - $0.71 Per pill twice a week. No other drug. We are also considering this option in the long term where we decide to extend the phase in later. Gefitinib will be offered in combination with the currently accepted regimens, which include one of these two drugs. We need an interim analysis to check that gefitinib is safe and the dose effective is safe. It might also be helpful to get more detailed reports of adverse events, including those where symptoms develop after 1 week of treatment (see our safety page for more details).

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